Giovanni Sartori's Advances in Friedel-Crafts Acylation Reactions: Catalytic PDF

By Giovanni Sartori

ISBN-10: 1420067923

ISBN-13: 9781420067927

Used within the construction of a large variety of positive chemical substances and prescribed drugs, the Friedel-Crafts acylation response represents an artificial strategy of nice curiosity to natural chemists of academia and undefined. approximately forty years because the final significant treatise at the subject and reflecting the starting to be emphasis on green technology, Advances in Friedel-Crafts Acylation Reactions: Catalytic and eco-friendly methods makes a speciality of the way to make this response extra economically and environmentally pleasant through the use of green acylating stipulations, therefore minimizing the formation of waste and reducing construction costs.

Divided into 4 components, the booklet explores stoichiometric acylations, catalytic homogeneous acylations, catalytic heterogeneous acylations, and phenol acylations. it truly is established in keeping with the function performed by means of the catalyst within the activation of reagents in addition to within the diverse modes of regioselectivity encountered within the acylation of arenes, fragrant ethers, and phenols.

Incorporating examples of all acid-catalyzed Friedel-Crafts acylation reactions, the textual content considers vintage Lewis and Brönsted acid forms besides extra cutting edge and complicated multicomponent superacid catalysts. those diversity from infrequent earth triflates or triflimides and their blend with ionic beverages to metal-promoted zeolites and zeotypes, clays, polymetal oxides, sulfated zirconia, heteropoly acids, and Nafion. The booklet emphasizes the most important business purposes, offering a severe overview of the diversities, benefits, and downsides of homogeneous and heterogeneous catalysis.

Helping readers to higher comprehend the mechanism of the Friedel-Crafts acylation, the examples within the booklet substantiate the improvement of more beneficial catalysts and extra selective strategies completed over the last few many years, allowing to embark on a more secure and extra effective synthesis of fragrant ketones for the manufacture of a big selection of products.

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Extra resources for Advances in Friedel-Crafts Acylation Reactions: Catalytic and Green Processes

Example text

2007. Microwave‑assisted synthesis of rufigallol and its novel room‑temperature liquid crystalline derivatives. Tetrahedron Lett. 48: 4399–4402. Chapter 2: Stoichiometric acylations 31 39. , and Casnati, G. 1992. Acylation of aroyl chlorides via a template Friedel–Crafts process: synthesis of indan‑1,3‑diones. J. Chem. , Perkin Trans. 1 2985–2988. 40. , and Tao, X. 1993. Friedel– Crafts coordinated process: highly selective synthesis of hydroxynaphtho‑ quinones. J. Org. Chem. 58: 840–843. 41. , and Meth‑Cohn, O.

A general synthetic route for l‑substi‑ tuted 4‑oxygenated β‑carbolines (Synthetic studies on indoles and related compounds 41). Tetrahedron 53: 1593–1606. 22. Olah, G. A. 1964. Friedel‑Crafts and related reactions. London: Interscience, 3: 911–960. 23. Fillion, E. and Fishlock, D. 2003. Convenient access to polysubstituted 1‑indanones by Sc(OTf)3‑catalyzed intramolecular Friedel–Crafts acylation of benzyl Meldrum’s acid derivatives. Org. Lett. 5: 4653–4656. 24. Sharma, A. , Subramani, A. , and Gorman, C.

And Flitsch, W. 1985. Ring‑chain tautomerism, ed. Katritzky, A. R. New York: Plenum Press. 34. , and Foglio, F. 1990. A new methodological approach to anthraquinone and antrhacyclinone synthesis. Gazz. Chim. Ital. 120: 13–19. 35. , and Pellinghelli, M. A. 1995. An investigation of the reaction mechanism of the bis‑acylation of aromatics with o‑phthaloyl dichlorides: regioselective synthesis of anthraquinones. J. Org. Chem. 60: 6588–6591. 36. , and Robles, P. 1987. Metal template ortho‑­ acylation of phenols; a new general approach to anthracyclinones.

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Advances in Friedel-Crafts Acylation Reactions: Catalytic and Green Processes by Giovanni Sartori

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