By Jean D. Sipe
A first-stop reference on proteins linked to amyloidosis. This publication is the 1st to offer a scientific assessment of all identified fibril-forming proteins, together with their biochemical features and pathophysiology. It considers the clinically well-known amyloid proteins which are identified to be linked to the amyloid protein folding issues, facing their universal structural and thermodynamic good points that result in amyloid fibril formation and affliction. Emphasis is at the thermodynamics of protein folding, the constitution and physiologic results of universal oligomeric and subfibrillar intermediates and the impact of the extracellular matrix and mobile trafficking and metabolism at the genesis and catabolism of beta pleated sheet proteins. The chapters on particular amyloid proteins all stick to a standard constitution, permitting easy accessibility to the specified biochemical and clinical info, making this a useful instrument for clinicians and researchers alike.
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Extra resources for Amyloid Proteins: The Beta Sheet Conformation and Disease
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Amyloid Proteins: The Beta Sheet Conformation and Disease by Jean D. Sipe