By Kevin D. Altria (auth.)
During the 1980's the research of prescription drugs used to be ruled via excessive Perfor mance Liquid Chromatography (HPLC). different separative thoughts akin to fuel Chromato graphy and skinny Layer Chromatography provided choices yet their quantitative capabili ties and/or solute variety couldn't technique that of HPLC. nearly all of prescription drugs are ionic and it'd be average to imagine that electrophoresis will be beneficial within the research of prescribed drugs. even though, the electrophore tic tools on hand within the 1980's have been labour in depth and hired post-separation detection tactics. in the course of the overdue 1980's and early 1990's vast examine was once con ducted into the chances of engaging in electrophoretic separations in capillaries. This procedure allowed online detection and will be played on absolutely automatic gear. This study ended in the arrival of contemporary day capillary electrophoresis (CE) tools which provide comparable functionality and automation degrees to that of HPLC. learn used to be additionally excited by constructing purposes for CE and specific realization was once paid to functions in the pharmaceutical research sector. those functions proved that CE will be utilized to quite a lot of drug forms together with water insoluble and impartial compounds. the facility to accomplish effective chiral separations of gear additionally elevated the recognition of the method. CE with oblique UV detection has develop into proven as an easy and potent substitute to ion-exchange chromatography for the decision of small inorganic or natural ions.
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Additional resources for Analysis of Pharmaceuticals by Capillary Electrophoresis
This stacking may result in up to a ten-fold increase in oncapillary sample concentration which may then cause precipitation problems. Precipitation problems may lead to extremely poor peak shapes with resulting difficulties in accurate integration. The sample and internal standard concentration, dissolving solvent and electrolyte composition should all be appropriately optimised during method development. 7 Other factors affecting precision Several minor factors can give rise (48) to injection volume variability.
34. Thomas BR, Fang XG, Chen X , Tyrell RJ, and Ghodbane S, Validated micellar electrokinetic capillary chromatography method for the quality control of the drug substances hydrochlorothiazide and chlorothiazide, 1. , 657 (1994) 383-394. 35. Sakodinskaya I K, Desiderio C, Nardi A, and Fanali S, Micellar electrokinetic chromatographic study of hydroquinone and some esters, 1. , 596 (1992) 95-100. 36. Weinberger R and Albin M, Quantitative micellar electrokinetic capillary chromatography: linear dynamic range, 1.
Kuhn R and Hoffstetter-Kuhn, in Capillary Electrophoresis: Principles and Practice, SpringerVerlag Press, Berlin, 1993. 4. Camilleri p, in Capillary Electrophoresis: Theory and Practice, CRC Press, Boca Raton, 1993. 5. Altria KD, Ed. Capillary Electrophoresis Guidebook - Principles, Operation and applications, Humana Press, Totowa, 1995. 6. H Watzig, Appropriate calibration functions for capillary electrophoresis I. Precision and sensitivity using peak areas and heights, J. Chromatogr. A, 700 (1995) 1-7.
Analysis of Pharmaceuticals by Capillary Electrophoresis by Kevin D. Altria (auth.)