By Joachim W. Fluhr, Peter Elsner, Enzo Berardesca, Howard I. Maibach
Bioengineering of the outside, or extra exactly the biophysical review of epidermis body structure, is relocating swiftly from a descriptive method of a deeper realizing of biophysical and biochemical tactics. This moment version of the preferred textual content Bioengineering of the surface: Water and Stratum Corneum displays the development within the box, concentrating on the dramatically more suitable realizing of dermis body structure. particularly, it reports the shift in our realizing of the stratum corneum from an inert surrounding sheet to a biologically energetic compartment.
The stratum corneum is the interface among the occasionally harsh surroundings and the interior turmoil of the human physique. according to quite a few fresh guides, this ebook explains the mechanisms serious about stratum corneum barrier functionality and hydration. It displays 10 years of development not just of the non-invasive biophysical evaluate of dermis body structure parameter, but additionally of the perfection of the to be had units. It brings all examine on epidermal water and transepidermal water loss in overall healthiness and disorder up to date with the revision of present chapters in addition to further chapters from new participants on hydration and itching. This version additionally contains new instructions at the standardization of measurements.
Bioengineering of the surface will improve communique in the examine neighborhood and should be precious for scientists within the pores and skin bioengineering box through offering equipment that provide trustworthy and reproducible techniques for product checking out within the pharmaceutical and beauty industries, in addition to for uncomplicated study
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Additional resources for Bioengineering of the Skin: Water and the Stratum Corneum, 2nd Edition
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1 Structural and functional consequences of stratum corneum acidification. Stratum Corneum pH and Ions — Distribution and Importance 29 high-resolution methods that focus on microdomains, such as fluorescence lifetime imaging microscopy [7,8] and electron spin resonance imaging , have been employed to assess SC pH. C. MECHANISMS LEADING TO SC ACIDIFICATION The “acid mantle” is the combined effect of the action of a number of endogenous and exogenous mechanisms. The endogenous mechanisms include enzymatic processes and membrane antiporters/pumps, whereas the exogenous mechanisms comprise free fatty acids from sweat and sebum and hydrolytic products of filaggrin, microbial metabolites, and lactic acid from eccrine glands.
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Bioengineering of the Skin: Water and the Stratum Corneum, 2nd Edition by Joachim W. Fluhr, Peter Elsner, Enzo Berardesca, Howard I. Maibach